Paper 1 SCIENTIFIC PAPER: PROTON PUMP INHIBITORS The scientific paper assignments in this course p ...

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Paper 1 SCIENTIFIC PAPER: PROTON PUMP INHIBITORS The scientific paper assignments in this course provide students the opportunity to expand their critical thinking and problem-solving capacities. They encourage scientific inquiry, literature review and scientific communication of molecular mechanisms that support cellular processes in health and disease states. INSTRUCTIONS From the assigned article found in the Learn section of this module, there are several significant issues with the long-term use of proton pump inhibitors (PPI). 1. Discuss the symptoms for which PPIs are prescribed and the intended target of these drugs. 2. Next, address an organelle that would also be affected by these drugs. 3. Based on the function of that organelle, do the issues on the website make biological sense? 4. Lastly, propose an alternative approach for a patient with these symptoms that would not require him or her to remain on PPIs long-term. Does your approach address the source of their symptoms? You should employ at least five peer-reviewed scientific sources/literature including review articles in your research on the topic and be sure to use the AMA writing format. There is a two (2)-page length limit on this paper, but it should be detailed, comprehensive, well organized and should have the appropriate language for scientific communication. Paper 2 SCIENTIFIC PAPER: HYPOCHOLESTEROLEMIC AGENTS ASSIGNMENT INSTRUCTIONS OVERVIEW The scientific paper assignments in this course provide students the opportunity to expand their critical thinking and problem-solving capacities. They encourage scientific inquiry, literature review and scientific communication of molecular mechanisms that support cellular processes in health and disease states. INSTRUCTIONS Work from the Brown and Goldstein lab (in the Familial Hypercholesterolemia article in the Learn section) provided insights into cholesterol homeostasis that were used to develop several of the LDL cholesterol-lowering therapies, including statins that remain in use today. However, in some patients, statins were not as effective as expected, suggestive of additional mechanisms regulating the LDL receptor. Investigate other LDL cholesterol-lowering therapies (other than PCSK-9 inhibitors), select 1, and compare the mechanisms of action between the class of drug you select and statins. Include side effects for both types of drugs and information on their efficacy. You should employ at least five peer-reviewed scientific sources/literature including review articles in your research on the topic and be sure to use the AMA writing format. There is a two (2)-page length limit on this paper, but it should be detailed, comprehensive, well organized and should have the appropriate language for scientific communication.