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A patient weighs 70 kg and has been prescribed digoxin to treat heart failure. The daily dose was in ...

A patient weighs 70 kg and has been prescribed digoxin to treat heart failure. The daily dose was increased gradually and reached 600 mcg on day 25. Calculate the stationary (steady-state) concentration of the drug in the blood. Is it possible to further increase the dose? Reference data: bioavailability F = 70%; volume of distribution Vd = 6.29 L/kg; half-life T1/2 is about 40 hours; therapeutic range 0.8 to 2 ng/mL. Show the dosage regimen of the drug on a graph.

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